Compound Library

Blend / Aromatase Inhibitor

Anastrozole + Exemestane Rotation

Protocol of rotating between reversible (Anastrozole) and suicidal (Exemestane) AIs. Prevents tolerance to either. Ensures even with missed doses, some permanent aromatase deactivation remains.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference doseAnastrozole 0.5 mg 2x/week alternating with Exemestane 12.5 mg 2x/week
Half-life36 hours
Risk flagmoderate
Regulatory noteResearch-only flag

Side effects and watch-outs

  • All AI side effects apply — see individual entries
  • Risk of over-suppression if both used simultaneously
  • Titrate to bloodwork — never use blindly