Side effects and watch-outs
- Joint pain at over-suppressed E2
- Bone density reduction with chronic use
- Mood changes
- Always titrate to bloodwork not symptoms
- Avoid if E2 is already in range without AI
Ancillary / Aromatase Inhibitor
Anastrozole Microdose (0.125mg EOD)
Ultra-low dose anastrozole protocol for sensitive users or those on lower TRT doses. 0.125 mg every other day provides gentle aromatase suppression without crashing E2. Popularised by TRT clinics.
Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.