Supplement / Adaptogen

Ashwagandha (KSM-66)

Adaptogenic herb (Withania somnifera). Reduces cortisol, modestly increases testosterone in stressed/hypogonadal men, reduces anxiety, improves sleep. KSM-66 extract (5% withanolides) is most clinically validated form.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose300–600 mg/day (KSM-66 extract, with food)

Half-life10 hours

Risk flaglow

Regulatory noteReview required

Side effects and watch-outs

Thyroid stimulation (may raise T4/T3 — monitor thyroid function)
Drowsiness
GI upset (take with food)
Rare: liver injury at very high doses
⚠️ Avoid in autoimmune thyroid conditions (Hashimoto's, Graves')
Avoid in pregnancy
Interactions with sedatives and immunosuppressants