Ancillary / Metabolic Support

Berberine

Plant alkaloid activating AMPK (same pathway as Metformin). Clinically significant blood glucose lowering, cholesterol reduction, and gut microbiome modulation. Often called 'natural Metformin'. Take immediately before meals.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose500 mg 2–3x/day immediately before meals

Half-life4 hours

Risk flaglow

Regulatory noteReview required

Side effects and watch-outs

⚠️ GI distress (cramping, diarrhoea — common on initiation — start with 1 dose/day)
⚠️ Hypoglycaemia risk when combined with diabetes medications, insulin, or other insulin sensitisers
CYP3A4 inhibitor — check all pharmaceutical interactions
Constipation at lower doses
⚠️ Avoid in pregnancy
⚠️ Berberine + Metformin significantly increases hypoglycaemia risk