Compound Library

Supplement / Performance

Creatine Monohydrate

Most researched sports supplement. Increases phosphocreatine stores for high-intensity performance, strength, lean mass, and cognitive function. Thousands of studies confirm safety.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose3–5 g/day. Optional loading: 20 g/day for 5 days then 5 g/day.
Half-life3 hours
Risk flaglow
Regulatory noteReview required

Side effects and watch-outs

  • Water retention (intramuscular — normal and beneficial)
  • GI distress if loading phase used (split doses)
  • Kidney concerns not supported by research in healthy individuals — widely considered a myth
  • One of the safest and most studied performance supplements