Peptide / Pain

Dermorphin

Naturally occurring opioid heptapeptide from South American frog skin. 30–40× more potent than morphine at μ-opioid receptor. Extreme analgesic efficacy. No human therapeutic approval. Banned in horse racing. Extreme addiction and respiratory depression risk.

Build protocol outline Open dose calculator TNHL ebooks

Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference doseResearch only — no safe human protocol established

Half-life0.5 hours

Risk flagextreme

Regulatory noteResearch-only flag

Side effects and watch-outs

⚠️ EXTREME RISK — potent opioid with high addiction liability
⚠️ Respiratory depression — potentially fatal at elevated doses
Physical and psychological dependence
Tolerance develops rapidly
Nausea and vomiting
Sedation
Constipation
⚠️ No established human therapeutic dosing — do not use without medical supervision
⚠️ Fatalities reported at supratherapeutic doses