Side effects and watch-outs
- Headache (common on initiation)
- Urine darkening (harmless)
- GI distress
- ⚠️ At very high doses may paradoxically increase oestrogen
- Nausea
- Generally well tolerated at standard doses
Supplement / Hormonal
Diindolylmethane (DIM)
Cruciferous vegetable metabolite. Modulates oestrogen metabolism — shifts towards less potent 2-hydroxy oestrogen metabolites. Used to manage oestrogen on TRT without fully suppressing it like an AI.
Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.