Hormones / Women's HRT

Estradiol (Bioidentical E2)

Bioidentical estradiol — most potent and primary estrogen. Available as transdermal patches, gels, creams, oral tablets, injections, and vaginal preparations. Essential for bone health, cardiovascular protection, cognitive function, and quality of life in peri/post-menopausal women. Also used in transgender HRT.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dosePatch: 0.05–0.1mg/day. Gel: 1–2 pumps daily. Injection: 2–5mg IM every 7–14 days.

Half-life18 hours

Risk flaglow

Regulatory noteFDA-approved context noted

Side effects and watch-outs

Breast tenderness
Bloating and water retention
Nausea
Headache
Mood changes
Spotting/bleeding (without progesterone)
VTE risk (oral route — transdermal safer)
Increased breast cancer risk with prolonged use (debated with bioidentical)