Hormones / Women's HRT/Trans

Estradiol Valerate (injectable)

Long-acting injectable estrogen ester. Popular in transgender HRT and as an alternative to transdermal E2. More stable blood levels than oral. Administered IM or SubQ.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose2–6mg IM every 7 days OR 2–4mg IM every 5 days.

Half-life72 hours

Risk flaglow

Regulatory noteFDA-approved context noted

Side effects and watch-outs

Injection site reaction
Breast tenderness
VTE risk
Headache
Mood changes
Nausea