Side effects and watch-outs
- Minimal systemic effects at vaginal doses
- Breast tenderness (oral)
- Uterine stimulation at high oral doses
- Headache
Hormones / Women's HRT
Estriol (E3)
Weakest natural estrogen, primarily produced during pregnancy. Used in compounded HRT and vaginal creams for menopausal symptoms with potentially lower breast cancer risk than E2. Popular in tri-estrogen formulations. Strong evidence for vaginal atrophy treatment.
Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.