Compound Library

Ancillary / Aromatase Inhibitor

Exemestane (Aromasin)

Steroidal, irreversible ('suicidal') AI — permanently deactivates aromatase molecules. No oestrogen rebound on discontinuation. Does NOT negatively interact with Tamoxifen (unlike Anastrozole). Preferred AI by many experienced users.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose12.5–25 mg every other day (titrate to bloodwork)
Half-life27 hours
Risk flagmoderate
Regulatory noteFDA-approved context noted

Side effects and watch-outs

  • Joint pain if oestrogen is over-suppressed
  • Hot flushes
  • Bone density loss with chronic use
  • Mild androgenic activity (acne, hair loss possible)
  • Fatigue
  • ⚠️ Oestrogen crash possible — monitor bloodwork