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Compound Library

Peptide / Longevity

FOXO4-DRI (FOXO4-p53 Disruptor)

Senolytic peptide. Disrupts FOXO4-p53 interaction in senescent cells, triggering apoptosis. Selectively clears senescent cells while sparing healthy cells. Pulsed dosing only.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose10 mg/kg IV or SubQ 3x over 3 days (cycle every 1–3 months)
Half-life4 hours
Risk flagmoderate
Regulatory noteResearch-only flag

Side effects and watch-outs

  • Fatigue during cycle
  • Injection site reaction
  • ⚠️ Apoptosis of senescent cells — theoretical risk if used in cancer treatment
  • Limited human RCT data
  • Pulsed dosing mandatory — do not use continuously
  • Nausea