Compound Library

Ancillary / GnRH

Gonadorelin (GnRH)

Synthetic GnRH. FDA-approved. Pulsatile LH/FSH stimulator. Used on TRT as HCG alternative to maintain testicular function. Must be dosed twice daily — continuous use paradoxically suppresses the axis.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose100–150 mcg SubQ twice daily (morning and night)
Half-life0.1 hours
Risk flaglow
Regulatory noteFDA-approved context noted

Side effects and watch-outs

  • Injection site reaction
  • Headache
  • Nausea
  • Testicular discomfort (LH surge)
  • ⚠️ Continuous dosing SUPPRESSES the axis — must be pulsatile (twice daily minimum)
  • Rare: hypersensitivity reaction