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Compound Library

Peptide / GnRH

Gonadorelin (Kisspeptin Protocol)

Pulsatile GnRH protocol using kisspeptin pre-stimulation for superior HPTA restart. Kisspeptin (6 nmol/kg) administered 30 min before pulsatile Gonadorelin to amplify the pituitary response. Most advanced HPTA restoration protocol available.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference doseKisspeptin 6 nmol/kg SubQ then Gonadorelin 100 mcg pulsatile every 90 min × 8h
Half-life0.1 hours
Risk flagmoderate
Regulatory noteResearch-only flag

Side effects and watch-outs

  • LH surge — testicular discomfort
  • Nausea
  • Headache
  • Requires endocrine supervision for optimal pulsatile timing
  • Ovarian hyperstimulation risk in women