Peptide / GH Axis

HGH (Human Growth Hormone / Somatropin)

Recombinant human growth hormone. The gold standard GH replacement. Stimulates IGF-1 production, promotes lipolysis, muscle protein synthesis, collagen production, and bone density. Prescription required. IU-dosed. Quality source critical — counterfeits common.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference doseTRT/anti-aging: 1–2 IU/day. Performance: 2–4 IU/day. Split morning and post-workout.

Half-life3.5 hours

Risk flagmoderate

Regulatory noteFDA-approved context noted

Side effects and watch-outs

⚠️ Acromegaly risk at chronic supraphysiological doses (> 4 IU/day)
Carpal tunnel syndrome (fluid retention in wrist)
Joint pain
Water retention — especially at initiation
Insulin resistance — monitor fasting glucose
Headache
Injection site reaction
⚠️ Never use if active malignancy — GH is mitogenic
Morning fatigue if dosed at night (normal GH pulse disruption)
Hypoglycaemia if stacked with insulin