Compound Library

SARM / GH Secretagogue

Ibutamoren Mesylate (MK-677)

Oral growth hormone secretagogue / ghrelin mimetic. Not technically a SARM but grouped with them. Reliably increases GH and IGF-1. Once daily oral dosing. Popular for muscle gain, fat loss, sleep quality improvement, skin quality. Causes significant insulin resistance.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose10–25mg oral once daily (before bed preferred).
Half-life24 hours
Risk flagmoderate
Regulatory noteResearch-only flag

Side effects and watch-outs

  • Water retention (very common)
  • Increased appetite/hunger
  • Insulin resistance (significant — monitor glucose)
  • Lethargy
  • Joint pain
  • Elevated prolactin (some users)
  • Carpal tunnel syndrome at higher doses