Compound Library

Supplement / Hormonal

Indole-3-Carbinol (I3C)

Cruciferous vegetable compound. Precursor to DIM. Modulates oestrogen metabolism and acts as anticarcinogen in GI tract. Weaker and less stable than DIM.

Build protocol outline Open dose calculator TNHL ebooks
Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose200–400 mg/day
Half-life3 hours
Risk flaglow
Regulatory noteReview required

Side effects and watch-outs

  • GI distress
  • Nausea
  • Headache
  • DIM is generally preferred (more stable/potent)
  • ⚠️ High doses may have paradoxical effects on oestrogen signalling