Compound Library

Peptide / Gut & Repair

Larazotide Acetate

Tight junction regulator reducing intestinal permeability (leaky gut). Most studied for coeliac disease. Oral administration — poorly absorbed systemically (intentional). Failed FDA Phase 3 but widely used in research.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose0.5–2 mg oral 3x daily before meals
Half-life1 hours
Risk flaglow
Regulatory noteResearch-only flag

Side effects and watch-outs

  • Headache
  • Nausea
  • Abdominal pain
  • Diarrhoea
  • Relatively well tolerated in Phase 2 trials
  • Not recommended in pregnancy