Compound Library

Peptide / Neuroprotective

Leu-Enkephalin

Endogenous opioid pentapeptide. Pain modulation, mood enhancement. Extremely short half-life. Research for chronic pain, depression, and immune modulation.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose200–500 mcg SubQ or intranasal
Half-life0.03 hours
Risk flagmoderate
Regulatory noteResearch-only flag

Side effects and watch-outs

  • Euphoria (dose-dependent)
  • Mild sedation
  • Nausea
  • ⚠️ Opioid receptor activity — potential for dependence with frequent use
  • Very short half-life — rapid action and offset