SARM / Classic SARM

Ligandrol (LGD-4033)

Most potent SARM for lean muscle gain. Significant HPTA suppression comparable to mild testosterone. Popular for bulking with less water retention than testosterone. NOT FDA-approved.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose5–10 mg/day. Maximum 8–10 weeks.

Half-life36 hours

Risk flaghigh

Regulatory noteResearch-only flag

Side effects and watch-outs

⚠️ Significant HPTA suppression — full PCT required (equivalent to mild testosterone cycle)
Water retention
Mild HDL suppression
Liver enzyme elevation — LFTs required
Fatigue on cycle
Elevated oestrogen in some users
Requires comprehensive PCT (Nolvadex 20–40 mg/day for 4–6 weeks)