Ancillary / Immune/Pain

Low-Dose Naltrexone (LDN)

At ultra-low doses (1.5–4.5 mg), paradoxically upregulates endorphin production and modulates microglial neuroinflammation. Compounded — not standard pharmacy. Used for autoimmune conditions, fibromyalgia, Crohn's, and chronic pain.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose1.5–4.5 mg at bedtime (compounded formulation)

Half-life4 hours

Risk flaglow

Regulatory noteReview required

Side effects and watch-outs

Vivid dreams/insomnia initially (usually resolves in 1–2 weeks)
Mild nausea on initiation
Headache
⚠️ Blocks ALL opioid medications — do not combine with opioid pain medications or drugs
Compounded product — formulation varies by pharmacy