Supplement / Antioxidant

Melatonin High-Dose (Anti-Inflammatory)

At doses >10 mg, melatonin functions as a potent antioxidant and anti-inflammatory beyond its sleep role. Used in cancer supportive care and inflammatory conditions. Very different from physiological sleep dosing.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose10–100 mg/day (anti-inflammatory protocol — not sleep)

Half-life0.75 hours

Risk flagmoderate

Regulatory noteReview required

Side effects and watch-outs

⚠️ Significant morning grogginess and drowsiness at high doses
Hypothermia
Vivid dreams
⚠️ Hormonal disruption with chronic high doses
Headache
Do not drive/operate machinery within 8 hours of high doses
Very different dose from sleep use (0.3 mg) — do not confuse