Ancillary / Longevity/Metabolic

Metformin

FDA-approved biguanide antidiabetic (Glucophage). Used off-label in longevity protocols — activates AMPK, the same pathway as caloric restriction. TAME longevity trial ongoing. Take with food and away from training sessions.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose500–2000 mg/day with food (titrate from 500 mg)

Half-life5 hours

Risk flaglow

Regulatory noteFDA-approved context noted

Side effects and watch-outs

GI distress on initiation (nausea, diarrhoea — titrate slowly)
Vitamin B12 depletion with long-term use — supplement
Rare: lactic acidosis in renal impairment
May blunt some training adaptations if taken peri-exercise
⚠️ Contraindicated in kidney disease (eGFR <30), liver disease, and excess alcohol use