SARM / GH Secretagogue

MK-677 (Ibutamoren)

Oral non-peptide ghrelin mimetic that elevates GH and IGF-1. Often categorised with SARMs but is a GH secretagogue. Convenient once-daily oral dosing. Major concern: water retention and insulin resistance with chronic use.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose12.5–25 mg oral once daily at night

Half-life24 hours

Risk flagmoderate

Regulatory noteResearch-only flag

Side effects and watch-outs

Significant water retention (very common)
Increased appetite
Lethargy/fatigue
Insulin resistance and elevated fasting glucose
Joint pain
Numbness/tingling hands
Raised IGF-1 (concern if pre-existing cancer — do not use)
Rare: glucose intolerance progressing to pre-diabetes with long-term use