Compound Library

Peptide / Longevity

MOTS-c

Mitochondrial-derived peptide encoded in mitochondrial DNA. Improves insulin sensitivity, activates AMPK, increases exercise capacity. Declines naturally with age. Strong research interest in metabolic disease and longevity.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose5–10 mg SubQ, 3–5x/week
Half-life0.5 hours
Risk flaglow
Regulatory noteResearch-only flag

Side effects and watch-outs

  • Hypoglycaemia risk (insulin sensitising — monitor blood glucose)
  • Injection site reaction
  • Fatigue on initiation
  • Nausea (uncommon)