Compound Library

Peptide / Cognitive

Orexin-A (Hypocretin-1)

Wakefulness-promoting neuropeptide. Deficient in narcolepsy. Intranasal administration shows cognition enhancement and vigilance in healthy subjects. Highly experimental.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose200–400 mcg intranasal (research only)
Half-life0.5 hours
Risk flagmoderate
Regulatory noteResearch-only flag

Side effects and watch-outs

  • Elevated heart rate and blood pressure
  • Anxiety
  • Insomnia if dosed too late
  • Appetite suppression
  • Very limited human safety data
  • Unknown long-term effects