Compound Library

Supplement / Performance

Phosphatidic Acid (PA)

Phospholipid that directly activates mTOR signalling independent of leucine/amino acids. Human trials show significant increases in muscle mass and strength vs placebo. Novel mechanism.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose750 mg/day (750 mg Mediator PA form for best evidence)
Half-life6 hours
Risk flaglow
Regulatory noteReview required

Side effects and watch-outs

  • GI distress (take with food)
  • Headache
  • Limited long-term data
  • Generally well tolerated in trials