Medication / Metabolic/Longevity

Pioglitazone (Actos)

PPAR-gamma agonist insulin sensitizer. Reduces ectopic fat, improves insulin sensitivity, anti-inflammatory. ITP mouse trial showed lifespan extension (males). Used in combination longevity protocols. Reduces NAFLD and metabolic syndrome.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose7.5–15mg oral daily (longevity protocol — lower than diabetes dose).

Half-life7 hours

Risk flagmoderate

Regulatory noteFDA-approved context noted

Side effects and watch-outs

Weight gain (edema)
Fluid retention
Heart failure risk (monitor)
Fracture risk (women)
Bladder cancer risk (debated)
Anemia
Headache