Supplement / Performance

Piperine (BioPerine)

Black pepper extract. Inhibits drug metabolism enzymes — dramatically increases absorption of many supplements and medications. Standard 5–20 mg added to stacks for enhanced bioavailability.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose5–20 mg with other supplements

Half-life3 hours

Risk flaglow

Regulatory noteReview required

Side effects and watch-outs

GI irritation at high doses
⚠️ Significantly increases absorption of medications — may increase drug effects and side effects
Avoid with medications with narrow therapeutic windows (e.g. thyroid hormones, blood thinners)
Generally well tolerated at standard doses