Compound Library

Ancillary / Hormonal

Progesterone (Bioidentical)

Bioidentical progesterone. Used by men on TRT for neurosteroid effects, sleep improvement, and to counter estrogen dominance. Also used by women for HRT. Oral progesterone converts to allopregnanolone (GABA-A positive allosteric modulator) — potent sleep aid.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose100–200 mg oral at bedtime
Half-life20 hours
Risk flaglow
Regulatory noteFDA-approved context noted

Side effects and watch-outs

  • Sedation (intended for sleep use)
  • Dizziness
  • Do not drive after taking
  • Morning grogginess at high doses
  • Generally well tolerated
  • In men: monitor DHT (5α-reduced to DHT)