Ancillary / Longevity

Rapamycin (Sirolimus)

mTOR inhibitor. FDA-approved immunosuppressant for organ transplant. Off-label longevity use — intermittent low-dose weekly dosing to inhibit mTORC1. One of the most researched longevity compounds. Requires physician oversight.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference doseLongevity protocol: 1–6 mg once weekly (intermittent)

Half-life63 hours

Risk flaghigh

Regulatory noteFDA-approved context noted

Side effects and watch-outs

⚠️ Immune suppression — increased infection risk
Mouth ulcers (aphthous stomatitis)
Impaired wound healing
Hyperlipidaemia
Insulin resistance at higher doses
Many drug interactions (CYP3A4 substrate)
⚠️ Physician oversight strongly recommended — profound effects on immune function