Supplement / Longevity

Resveratrol

Polyphenol from red wine and grapes. Activates SIRT1 and AMPK. Anti-inflammatory, cardioprotective. Trans-resveratrol is the active form. Poor oral bioavailability unless taken with fat. Combined with NMN/NR in many longevity protocols.

Build protocol outline Open dose calculator TNHL ebooks

Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose250–1000 mg trans-resveratrol daily (with fat-containing meal)

Half-life3 hours

Risk flaglow

Regulatory noteReview required

Side effects and watch-outs

GI upset (especially at high doses — diarrhoea)
Nausea
Interactions with blood thinners (anticoagulant activity)
May affect oestrogen metabolism — caution with hormone-sensitive conditions
Generally well tolerated at lower doses