Compound Library

Peptide / Cognitive

Semax

ACTH(4-7) heptapeptide analog developed in Russia. Boosts BDNF and NGF, improves focus, memory, attention. Clinically used in Russia for stroke recovery and cognitive enhancement. Intranasal delivery is highly bioavailable.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose100–900 mcg intranasal 2x/day
Half-life0.25 hours
Risk flaglow
Regulatory noteResearch-only flag

Side effects and watch-outs

  • Mild anxiety or overstimulation at high doses
  • Insomnia if taken too late
  • Headache
  • Mild nasal irritation
  • Rare: cortisol elevation
  • Receptor downregulation with chronic daily use — consider cycling