Side effects and watch-outs
- Generally very well tolerated at dietary doses
- GI upset at high doses
- Limited long-term clinical intervention data
- Wheat germ extract form may cause GI discomfort in gluten-sensitive individuals
Supplement / Longevity
Spermidine
Polyamine naturally found in wheat germ, aged cheese, and mushrooms. Induces autophagy. Associated with increased lifespan in animal models and reduced cardiovascular mortality in human cohort studies.
Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.