Compound Library

Medication / Cardiovascular/PDE5

Tadalafil (Cialis — Daily)

PDE5 inhibitor at low daily dosing improves endothelial function, reduces blood pressure, increases nitric oxide, and has cardiovascular protective effects beyond erectile function. 5mg/day protocol widely used for cardiovascular health, gym performance, and TRT support.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose2.5–5mg oral daily (longevity/CV). 10–20mg as needed.
Half-life17.5 hours
Risk flaglow
Regulatory noteFDA-approved context noted

Side effects and watch-outs

  • Headache
  • Flushing
  • Nasal congestion
  • Back pain
  • Hypotension when combined with nitrates (contraindicated)
  • Vision changes (rare)