Ancillary / SERM

Tamoxifen (Nolvadex)

SERM blocking oestrogen at breast tissue while stimulating LH/FSH for PCT. FDA-approved for breast cancer. Standard PCT medication. Drug interaction with Anastrozole — use Exemestane instead if AI needed alongside Nolvadex.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dosePCT: 20–40 mg/day for 4–6 weeks. Gynaecomastia: 20 mg/day

Half-life120 hours

Risk flagmoderate

Regulatory noteFDA-approved context noted

Side effects and watch-outs

Hot flushes (very common)
Mood changes
Reduced libido (raises SHBG)
⚠️ Rare: blood clots (DVT/PE — higher risk when combined with AAS)
Rare: uterine cancer with very long-term use (women)
Rare: visual disturbances
⚠️ Drug interaction: reduces Anastrozole blood levels by ~27% — combine with Exemestane instead