Antibiotic / Antibiotic

Trimethoprim-Sulfamethoxazole (TMP-SMX / Bactrim)

Combination sulfonamide antibiotic used in prescription contexts for susceptible infections. The profile highlights sulfa allergy, kidney/electrolyte monitoring, severe rash risk, warfarin interaction, and stewardship.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dosePrescription dosing depends on infection, organism, kidney function, age/weight, formulation, and clinician-directed duration. Verify official label and current guidance.

Half-lifeIntermediate; trimethoprim and sulfamethoxazole have different half-lives, commonly discussed around 8 to 12 hours depending on patient context. hours

Risk flaghigh

Regulatory noteReview required

Side effects and watch-outs

Nausea
Rash
Photosensitivity
Hyperkalemia risk
Kidney marker changes
Blood count changes
Severe skin reaction risk
C. difficile-associated diarrhea risk