Compound Library

Supplement / Longevity

Urolithin A

Gut microbiome metabolite from pomegranate and berry polyphenols. Activates mitophagy — the cellular recycling of damaged mitochondria. Phase 2 human trials show improved muscle endurance in older adults. Mitochondrial longevity compound.

Build protocol outline Open dose calculator TNHL ebooks
Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.
Reference dose500–1000 mg/day (Mitopure form for clinical evidence)
Half-life24 hours
Risk flaglow
Regulatory noteReview required

Side effects and watch-outs

  • Generally extremely well tolerated
  • GI distress at high doses
  • Mild fatigue on initiation (mitophagy activation)
  • Rare: allergic reaction