Peptide / Immune

VIP (Vasoactive Intestinal Peptide)

Endogenous neuropeptide with potent anti-inflammatory, vasodilatory, and immune-modulatory effects. Reduces inflammatory cytokines (TNF-α, IL-6). Used for CIRS (Chronic Inflammatory Response Syndrome), MCAS, long COVID, and pulmonary hypertension. Intranasal delivery. Requires mold-free environment — mold biotoxins neutralise effects.

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Educational reference only. This page does not diagnose, prescribe, or replace care from a licensed professional. Laws, availability, and clinical appropriateness vary by location.

Reference dose50 mcg intranasal 4x daily (Shoemaker protocol)

Half-life1 hours

Risk flagmoderate

Regulatory noteResearch-only flag

Side effects and watch-outs

⚠️ Must test for mold/CIRS before use — can worsen if biotoxins present
Flushing and vasodilation
Hypotension — especially on initiation
Nausea
Headache
VCS (visual contrast sensitivity) testing recommended before use
Palpitations
Generally well tolerated when CIRS is properly assessed